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  • One Brain, Two Computers
    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
    • The Active Role of Microglia in Healthy Brain
  • Projects
    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation
Professor Eric Lander  (MIT professor of biology, Founding Director of MIT's Broad Institute)
​
​Identifying Unmet Need for Pharmacological Tools to Modulate Microglial Over-Pruning of Synapses at the Root of Schizophrenia
2016 Talk at the Aspen Institute
Prof. Eric Lander discussing the 2016 discovery (link to scientific paper)  that the genes controlling how microglia prune synapses in the brain are dysregulated in people with schizophrenia.  

This work confirmed a genetic factor explaining why schizophrenic patients have lower synaptic density than healthy controls.  Microglia, the cells which prune synapses as the adolescent brain makes the transition to adulthood, essentially over do it in the context of schizophrenia.  

Lander suggests that the target is now to develop pharmacology which can inhibit this microglial process.  

​D-ETX is an example of this type of microglial modulating pharacology
​ COPYRIGHT 2016. BLUE BRIDGE LIFE SCIENCE ~ ALL RIGHTS RESERVED.
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  • Home
  • About
  • One Brain, Two Computers
    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
    • The Active Role of Microglia in Healthy Brain
  • Projects
    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation