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  • One Brain, Two Computers
    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
    • The Active Role of Microglia in Healthy Brain
  • Projects
    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation
ETX Data: Clinical
ETX  vs Lorazepam (Ativan) - Equivalent Anxiolytic Efficacy without Sedation
ETX Displays Equivalent Axiolytic Efficacy to Lorazepam (Ativan) at Day 28 in Human Clinical Trials (Nguyen et al, 2006)

Note: Lorazepam is the second most prescribed benzodiazpine in the USA Market - approximately 30 million prescriptions per year
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ETX Number of Responders  Significantly Higher than Lorazepam in Clinical Trial  (Nguyen et al, 2006)
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 ETX Does Not Induce Amnesia or Sedation as Compared to Lorazepam in Human Clinical Trials (Micallef et al, 2001)
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  • Home
  • About
  • One Brain, Two Computers
    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
    • The Active Role of Microglia in Healthy Brain
  • Projects
    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation