Documents
Microglial Dysregulation Implicated in Neurodegenerative Disease
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Multiple Sclerosis
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Acharjee et al, 2013, Altered Cognitive-emotional Behavior in Early Experimental Autoimmune Encephalytis - Cytokine and Hormonal Correlates, Brain, Behavior and Immunology
Mandolesi et al, 2015, IL-1Beta Dependent Cerebellar Synaptopathy in a Mouse Model of Multiple Sclerosis, Cerebellum
Daugherty et al, 2016, The hGFAP-driven Conditional Knockout is Protectice in a Mouse Model of Multiple Sclerosis, Scientific Reports
Rossi et al, 2014, Interleukin-1Beta Casues Excitotoxic Neurodegeneration and Multiple Sclerosis Disease Progression by Activating the Apoptotic Protein p53, Molecular Neurodegenerations
Sloka et al, 2013, Reduction in Microglial Activity in a Model of Multiple Sclerosis by Dipyridamolein, Journal of Neuroinflammation
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Alzheimer's and Other Age-Related Cognitive Decline (Including Post-Operative Delirium)
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Bilbo 2010, Early Life Infection is a Vulnerability Factor for Aging-Related Glial Alterations and Cognitive Decline, Neurobiology of Learning and Memory
Jendersen et al, 2017 The Alzheimer's Disease Risk Factors Apolipotprotein E and TREM2 Are Linked in a Receptor Signaling Pathway, The Journal of Neuroinflammation
Krasemann et al, 2017 The TREM2 APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases, Cell Press
Atagi et al, 2015, Apolipotprotein E is a Ligand for Triggering Receptor Expressed on Myeliod Cells 2 [microglia} (TREM2), The Journal of Biological Chemistry
Hong et al, 2016, Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Model, Nature
Hong et al, 2016, New Insights on the Role Microglia in Synaptic Pruning in Health and Disease, Current Opinion in Neurobiiology
Jalleh et al, 2012, Role of Microglia and Toll-like Receptor4 in the Pathophysiology of Delirium, Medical Hypotheses
Cecejiera et al, 2014, The Immunology of Delirium, NeuroimmunoModulation
Lynch, 2009, Age Related Neuro-Inflammatory Changes Negatively Impact on Neuronal Function, Frontiers in Aging Science
Norden et al, 2015, Microglial Priming and Enhanced Reactivity to Secondary Insult in Aging, Traumatic CNS Injury, and Neuro-degenerative Disease, Neuropharmacology
Norden & Godbout, 2013, Microglia of the Aged Brain: Primed to be Acitvated and Resistant to Regulation, Neurophathology and Applied Neurobiology
Hefendehl et al, 2014, Homeostatic and Injury-induced Microglial Behaviour in the Aging Brain. Aging Cell
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AlS
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Cady et al, 2014, TREM2 variant p.R47H as a Risk Factor for Sporadic Anyoitrophic Lateral Sclerosis, JAMA Neurology
Phillips and Rothstein, 2014, Glial Cells in Amyotrophic Lateral Sclerosis, Experimental Neurology
Corcia et al, 2012, Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis. PLoS One
Clinical Trial: A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects with Amyotrophic Lateral Sclerosis Clinical Trials.gov
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Parkinson's
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Gerhard, 2016, TSPO Imaging in Parkinsons Disorders, Clinical Translation Imaging
Lill et al, 2015, The Role of TREM2 as a Risk Factor in AD, Frontotemporal Lobolar Dementia, ALS and Parkinsons, Alzheimer's Dementia
Barcia, 2013, Glial-mediated Inflammation Underlying Parkinsonism, Scientifica
Zhuang et al, 2016, , Contribution of Pro-inflammatory Cytokine Signalling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway. Frontiers in Neurology
Noelker et al, 2013, Toll like Receptor 4 Mediates Cell Death in a Mouse MPTP Model of Parkinson's Disease. Scientific Reports
Wilms et al, 2006 Inflammation in Parkinson's Disease and other Neurodegenerative Diseases. Current Pharmaceutical Design
Hirsch, 2003, The Role of Glial Reaction and Inflammation in Parkinson's Disease, Annals of the New York Academy of Sciences
Hunot and Hirsch, 2003, Neuroinflammatory Processes in Parkinson's Disease. Annals of Neurology
Lull and Block, 2010 , Microglial Activation and Chronic Neurodegeneration, Neurotherapuetics
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Diseases of Retinal Degeneration
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