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    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
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    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation

Documents

Back to Video & Doc Resources

Microglial Dysregulation Implicated in Neurodegenerative Disease 

Multiple Sclerosis
Acharjee et al,  2013, Altered Cognitive-emotional Behavior in Early Experimental Autoimmune Encephalytis - Cytokine and Hormonal Correlates, Brain, Behavior and Immunology
Mandolesi et al, 2015, IL-1Beta Dependent Cerebellar Synaptopathy in a Mouse Model of Multiple Sclerosis, Cerebellum
Daugherty et al, 2016,  The hGFAP-driven Conditional Knockout is Protectice in a Mouse Model of Multiple Sclerosis, Scientific Reports
Rossi et al, 2014,  Interleukin-1Beta Casues Excitotoxic Neurodegeneration and Multiple Sclerosis Disease Progression by Activating the Apoptotic Protein p53, Molecular Neurodegenerations
Sloka et al, 2013,  Reduction in Microglial Activity in a Model of Multiple Sclerosis by Dipyridamolein, Journal of Neuroinflammation

Alzheimer's and Other Age-Related Cognitive Decline (Including Post-Operative Delirium)
Bilbo 2010, Early Life Infection is a Vulnerability Factor for Aging-Related Glial Alterations and Cognitive Decline, Neurobiology of Learning and Memory
Jendersen et al, 2017 The Alzheimer's Disease Risk Factors Apolipotprotein E and TREM2 Are Linked in a Receptor Signaling Pathway, The Journal of Neuroinflammation
Krasemann et al, 2017  The TREM2 APOE Pathway Drives the Transcriptional Phenotype of  Dysfunctional Microglia  in Neurodegenerative Diseases, Cell Press
Atagi et al, 2015, Apolipotprotein E is a Ligand for Triggering Receptor Expressed on Myeliod Cells 2 [microglia} (TREM2), The Journal of Biological Chemistry
Hong ​et al, 2016, Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Model, Nature
Hong ​et al, 2016, New Insights on the Role Microglia in Synaptic Pruning in Health and Disease, Current Opinion in Neurobiiology
Jalleh et al​, 2012, Role of Microglia and Toll-like Receptor4 in the Pathophysiology of Delirium, Medical Hypotheses
Cecejiera et al, 2014, The Immunology of Delirium,  NeuroimmunoModulation
Lynch, 2009, Age Related Neuro-Inflammatory Changes Negatively Impact  on Neuronal Function, Frontiers in Aging Science 
Norden et al​, 2015, Microglial Priming and Enhanced Reactivity  to Secondary Insult in Aging, Traumatic CNS Injury, and Neuro-degenerative Disease, Neuropharmacology
Norden & Godbout, 2013,   Microglia of the Aged Brain: Primed to be Acitvated and Resistant to Regulation, Neurophathology and Applied Neurobiology
Hefendehl et al, 2014,   Homeostatic and Injury-induced Microglial Behaviour in the Aging Brain.  Aging Cell


AlS
Cady et al, 2014,  TREM2 variant p.R47H as a Risk Factor for Sporadic Anyoitrophic Lateral Sclerosis, JAMA Neurology
Phillips and Rothstein, 2014,  Glial Cells in Amyotrophic Lateral Sclerosis, Experimental Neurology
Corcia et al, 2012,  Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis. PLoS One
Clinical Trial: A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects with Amyotrophic Lateral Sclerosis  Clinical Trials.gov

Parkinson's
Gerhard, 2016, TSPO Imaging in Parkinsons Disorders, Clinical Translation Imaging
Lill et al, 2015, The Role of TREM2 as a Risk Factor in AD, Frontotemporal Lobolar Dementia, ALS and Parkinsons, Alzheimer's Dementia
Barcia,  2013, Glial-mediated Inflammation Underlying Parkinsonism, Scientifica
Zhuang et al, 2016, , Contribution of Pro-inflammatory Cytokine Signalling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway. Frontiers in Neurology
Noelker et al, 2013,  Toll like Receptor 4 Mediates Cell Death in a Mouse MPTP Model of Parkinson's Disease. Scientific Reports
Wilms et al, 2006 Inflammation in Parkinson's Disease and other Neurodegenerative Diseases. Current  Pharmaceutical Design
Hirsch,  2003, The Role of Glial Reaction and Inflammation in Parkinson's Disease, Annals of the New York Academy of Sciences
Hunot and Hirsch,  2003, Neuroinflammatory Processes in Parkinson's Disease.  Annals of Neurology
Lull and Block, 2010 , Microglial Activation and Chronic Neurodegeneration,   Neurotherapuetics

Diseases of Retinal Degeneration
Roche et al, 2016,  Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.  PLOS One
Chen and Xu, 2015,  Parainflammation, Chronic Inflammation and Age Related  Macular Degeneration.  Mjournal of Leukocyte Biology
Madeira et al, 2014,  The Contribution of Microglial-Mediated Neuro-inflammation to Retinal Degeneratie Diseases.  Mediators of Inflammation
Karlstetter et al, 2014,  Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis.  Journal of NeuroInflammation
Scholz, et al, 2015,  Targeting Translocator Protein (18kDa) (TSPO) Dampens Pro-Inflammatory  Microglia Reactivity in Retina and Protects from Degeneration   Journal of Neuroinflammation
Scholz, et al, 2015,  Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration   Journal of Neuroinflammation
Wang et al, 2014  Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina,   The Jouranl of Neuroscience
Cukras et al, 2012,  Oral Minocycline for the Treatment of Diabetic Macular Edema(DME): results of a phase 1/11 Clinical Studay.  Investigative Opthamology and Visual Science
Clinical Trial - Timothy Gardner, Sponsor Phase 2  -- Evaluation of Doxycylcine Vs Placebo for Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
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  • Home
  • About
  • One Brain, Two Computers
    • Summary of Lessons Learned Since 2005 Rediscovery of Microglia
    • The Active Role of Microglia in Healthy Brain
  • Projects
    • BLS 101 - Project Contents >
      • Project Introduction
      • Video and Documentary Resources >
        • Video Resources - Microglia as a Therapeutic Target
        • Documents - Microglia in Health and Disease
        • Documents - Microglia Role in Neuro-developmental Disease & Disorder
        • Documents - Microglia Role in Neuro-degenerative Disease
        • Documents - Microglia Role in Neuropathic Pain Disorders & Opioid Side Effects
        • Documents - ETX Studies
      • Background: The Rationale for a Microglia Modulator >
        • Background Pt 1: Summary of Lessons Learned Since 2005 Rediscovery of Microglia
        • Background Pt 2: The Active Role of Microglia in Healthy Brain
        • Background Pt 3: Causal Role for Microglia in Neuro-degenerative Disease
        • Background Pt 4: Causal Role for Microglia in Neuro-developmental Disease
        • Bilbo Video Clip - An Unmet Need for Microglial Modulators
      • ETX - Select Data >
        • ETX Data: ETX vs Benzo (Lorazepam) - Clinical Data
        • ETX Data: ETX vs Benzo (Alprazolam) - Clinical Data
        • ETX Data: Microglial Modulation - CFA Monoarthritis Model
        • ETX Data: Microglial Modulation - EAE MS Model
        • ETX Data: Microglial Modulation-Intracerebral Hemorrhage Model
        • ETX Data: Inhibtion of Microglial Activation via TLR4 Ligands
        • ETX Data: Microglial Modulation-CCI Model of Traumatic Brain Injury
        • ETX Data: Microglial Modulation-Sciatic Cryolesion Model
      • ETX - Select Data - Neuropathic Pain >
        • ETX Data: CFA Induced Model of Neuropathic Pain
        • ETX Data: ETX Prevents & Cures Chemo-Induced Neuropathic Pain - 3 Models
        • ETX Data: Cuffed Nerve Model of Neuropathic Pain
      • Market and Competition >
        • Market: Anti-Anxiety Medications
        • Competition: Microglial Modulator Dev Programs
    • BLS 102 - Project Navigation